How a non-invasive biomarker could help with earlier breast cancer metastatic diagnosis?

Every fourteen seconds, a woman gets a breast cancer diagnosis somewhere in the world. Although treatments for early-stage and non-metastatic breast cancer are now possible thanks to medical advances, advanced stage and metastatic breast cancer is thought to be incurable and has a very poor prognosis. Because early identification of breast cancer metastasis is crucial to the condition's therapy, a group of researchers has identified a non-invasive biomarker that may facilitate an earlier diagnosis.


From the EVs of several metastatic breast cancer cell lines, a collection of protein expression profiles are gathered using an ultra-sensitive protein identification technique. They found that integrins v and 1 were persistently overexpressed in EVs with a strong metastatic background, among many other potential proteins. Fundamental understandings of the underlying processes of breast cancer metastasis have emerged as a result of the work. In addition to being clinically applicable, the research increases the understanding of EVs by revealing functionally different subgroups of EVs that are now easier to identify and study in order to comprehend their roles and potential as therapeutic targets in the context of tumour environments.

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